| 000 | 00938nam a2200157Ia 4500 | ||
|---|---|---|---|
| 008 | 220514s9999||||xx |||||||||||||| ||und|| | ||
| 020 | _a3-8322-2639-7 | ||
| 050 | _aWC 503 .B44 2004 | ||
| 100 | _aBeerenwinkel, N. | ||
| 245 | 0 | _aComputational analysis of HIV drug resistance data | |
| 260 |
_aAachen _bShaker Verlag _c2004 |
||
| 300 | _aviii, 180p. | ||
| 500 | _aExamines computational ways for the analysis of integrated viral sequence data, phenotopic resistance data and clinical data from HIV-infected patients. A mixture model of trees to describe probabilistically the evolution of drug resistance is introduced and a useful learning algorithm presented. A scoring function for drug combinations that includes estimating the genetic barrier of the combination therapy relative to the viral strain is developed to support therapy optimisation. | ||
| 650 | _aAcquired Immunodeficiency Syndrome|HIV|Drug Resistance | ||
| 942 |
_2lcc _cBK |
||
| 999 |
_c5966 _d5966 |
||