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001 9780429021732
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007 cr |||||||||||
008 190118s2019 nyua o 000 0 eng d
040 _aOCoLC-P
_beng
_erda
_epn
_cOCoLC-P
020 _a9780429664298
_q(ePub ebook) :
020 _a042966429X
020 _a9780429667015
_q(PDF ebook) :
020 _a0429667019
020 _a9780429661570
_q(Mobipocket ebook) :
020 _a0429661576
020 _a9780429021732
_q(ebook) :
020 _a0429021739
020 _z9780367076337 (hbk.)
020 _z9780815345916 (pbk.)
024 7 _a10.1201/9780429021732
_2doi
035 _a(OCoLC)1088920742
035 _a(OCoLC-P)1088920742
050 4 _aQH447
072 7 _aMED
_x008000
_2bisacsh
072 7 _aSCI
_x007000
_2bisacsh
072 7 _aSCI
_x017000
_2bisacsh
072 7 _aPSD
_2bicssc
082 0 4 _a611.018166
_223
100 1 _aSamuelsson, Tore,
_d1951-
_eauthor.
245 1 4 _aThe human genome in health and disease :
_ba story of four letters /
_cTore Samuelsson.
250 _a1st.
264 1 _aNew York :
_bGarland Science,
_c2019.
300 _a1 online resource :
_billustrations (colour)
336 _atext
_2rdacontent
336 _astill image
_2rdacontent
337 _acomputer
_2rdamedia
338 _aonline resource
_2rdacarrier
500 _aChapter 1. Introduction -- Chapter 2. A molecular disorder -- Chapter 3. A code of life -- Chapter 4. The genome -- Chapter 5. Variants in the human genome sequence and their biological significance -- Chapter 6. The critical protein coding sequences -- Chapter 7. Triplet repeats and neurodegenerative disorders -- Chapter 8. The untranslated parts of a message -- Chapter 9. Exons, introns and a royal bleeding disorder -- Chapter 10. The regulation of transcription -- Chapter 11. The non-coding RNAs -- Chapter 12. Computational methods are critical in the analysis of molecular sequences -- Chapter 13. Diagnosing the genome -- Chapter 14. Correcting genome errors -- Chapter 15. Epilogue.
520 _aThe human genome is a linear sequence of roughly 3 billion bases and information regarding this genome is accumulating at an astonishing rate. Inspired by these advances, The Human Genome in Health and Disease: A Story of Four Letters explores the intimate link between sequence information and biological function. A range of sequence-based functional units of the genome are discussed and illustrated with inherited disorders and cancer. In addition, the book considers valuable medical applications related to human genome sequencing, such as gene therapy methods and the identification of causative mutations in rare genetic disorders. The primary audiences of the book are students of genetics, biology, medicine, molecular biology and bioinformatics. Richly illustrated with review questions provided for each chapter, the book helps students without previous studies of genetics and molecular biology. It may also be of benefit for advanced non-academics, which in the era of personal genomics, want to learn more about their genome. Key selling features: Molecular sequence perspective, explaining the relationship between DNA sequence motifs and biological function Aids in understanding the functional impact of mutations and genetic variants Material presented at basic level, making it accessible to students without previous studies of genetics and molecular biology Richly illustrated with questions provided to each chapter
588 _aOCLC-licensed vendor bibliographic record.
650 0 _aHuman genome.
650 0 _aHuman gene mapping.
650 7 _aMEDICAL / Biochemistry
_2bisacsh
650 7 _aSCIENCE / Life Sciences / Biochemistry
_2bisacsh
650 7 _aSCIENCE / Life Sciences / Cytology
_2bisacsh
856 4 0 _3Read Online
_uhttps://www.taylorfrancis.com/books/9780429021732
856 4 2 _3OCLC metadata license agreement
_uhttp://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf
942 _2lcc
_cEBK
999 _c18330
_d18330