000 00843nam a2200157Ia 4500
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020 _a92 4 154678 6
050 _aQV 602 .W67 2005
110 _aWorld Health Organization
245 0 _aChemical-specific adjustment factors for interspecies differences and human variability
260 _aGeneva
_bWorld Health Organization
_c2005
300 _aiv, 96p.
500 _aProvides information intended to guide risk assessors on the integration of quantitative data on interspecies differences or human differences in toxicokinetics and toxicodynamics into dose/concentration-response evaluation through the development of chemical-specific adjustment factors (CSAFs). The kind of data that can be used to develop a CSAF is portrayed.
650 _aMetabolism|Pharmacokinetics
942 _2lcc
_cBK
999 _c1057
_d1057