Medicinal Chemistry of Neglected Tropical Diseases [electronic resource] : Advances in the Design and Synthesis of Antimicrobial Agents.

Description based upon print version of record.

Cover; Title Page; Copyright Page; Preface; Table of Contents; 1: Key Concepts in Assay Development, Screening and the Properties of Lead and Candidate Compounds; 2: The Application of Fragment-based Approaches to the Discovery of Drugs for Neglected Tropical Diseases; 3: Chemical Hybridization Approaches Applied to Natural and Synthetic Compounds for the Discovery of Drugs Active Against Neglected Tropical Diseases; 4: Current Inhibitors of Dengue Virus: An Overview; 5: Overview of Drugs used Against Zika Virus; 6: Chikungunya Virus Infection: A Review of its Control and Treatment

7: Recent Advances in Repositioning Non-Antibiotics against Tuberculosis and other Neglected Tropical Diseases8: Prospects of Pre-clinical [6.6.0] Bicyclic Nitrogen Heterocycles in the Treatment of Tuberculosis; 9: Progress in Antimalarial Drug Discovery and Development; 10: Hits and Lead Discovery in the Identification of New Drugs against the Trypanosomatidic Infections; 11: New Chemical Scaffolds to Selectively Target the Trypanothione Metabolism; 12: The Renewal of Interest in Nitroaromatic Drugs: Towards New Anti-Kinetoplastid Agents

13: New Biological Targets for the Treatment of Leishmaniasis14: Curcumin and Neglected Infectious Diseases; 15: An Overview of Helminthiasis: Current State and Future Directions; Index; Color Plate Section

Medicinal Chemistry of Neglected and Tropical Diseases: Advances in the Design and Synthesis of Antimicrobial Agents consolidates and describes modern drug discovery and development approaches currently employed to identify effective chemotherapeutic agents for the treatment of Neglected Tropical Diseases (NTDs) from a medicinal chemistry perspective. Chapters are designed to cater to the needs of medicinal chemists who work with chemotherapeutic developments for NTDs, as well as serve as a guide to budding medicinal chemists who wish to work in this area. It will introduce rational drug design approaches adopted in designing chemotherapeutics and validated targets available for the purpose.

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