TY  - BOOK
AU  - Beerenwinkel, N.
TI  - Computational analysis of HIV drug resistance data
SN  - 3-8322-2639-7
AV  - WC 503 .B44 2004 
PY  - 2004///
CY  - Aachen
PB  - Shaker Verlag
KW  - Acquired Immunodeficiency Syndrome|HIV|Drug Resistance
N1  - Examines computational ways for the analysis of integrated viral sequence data, phenotopic resistance data and clinical data from HIV-infected patients. A mixture model of trees to describe probabilistically the evolution of drug resistance is introduced and a useful learning algorithm presented. A scoring function for drug combinations that includes estimating the genetic barrier of the combination therapy relative to the viral strain is developed to support therapy optimisation
ER  -