TY  - BOOK
AU  - Pfannkuch,Friedlieb
AU  - Suter-Dick,Laura
TI  - Predictive toxicology: from vision to reality 
T2  - Methods and principles in medicinal chemistry
SN  - 9783527336081
AV  - RA 1211 .P74  2015
PY  - 2015///]
CY  - Weinheim
PB  - Wiley-VCH
KW  - Toxicology
KW  - Drugs
KW  - Toxicity testing
KW  - Drug development
KW  - Safety measures
KW  - Side effects
KW  - Mathematical models
KW  - Drug-Related Side Effects and Adverse Reactions
KW  - Models, Theoretical
KW  - methods
KW  - Toxicogenetics
KW  - Toxicologie
KW  - Médicaments
KW  - Toxicité
KW  - Développement
KW  - Sécurité
KW  - Mesures
KW  - Effets secondaires
KW  - Modèles mathématiques
KW  - toxicology
KW  - aat
KW  - mathematical models
KW  - fast
KW  - Wirkstoff
KW  - gnd
KW  - Toxikologie
N1  - Includes bibliographical references and index; Introduction to Predictive Toxicology Tools and Methods / Laura Suter-Dick and Friedlieb Pfannkuch -- In silico toxicology : Current Approaches and Future Perspectives to Predict Toxic Effects with Computational Tools / Thomas Steger-Hartmann -- In silico approaches: Data Management : Bioinformatics / Arnd Brandenburg, Hans Gmuender, and Timo Wittenberger -- Role of Modeling and Simulation in Toxicology Prediction / Antje-Christine Walz, Hans Peter Grimm, Christophe Meille, Antonello Caruso, Neil Parrott, and Thierry Lavé -- Genomic Applications for Assessing Toxicities of Liver and Kidney Injury / Philip Hewitt and Esther Johann -- Use of Toxicogenomics for Mechanistic Characterization of Hepatocarcinogens in Shorter Term Studies / Heidrun Ellinger-Ziegelbauer -- Discovery and Application of Novel Biomarkers / Timothy W. Gant, Emma L. Marczylo, and Martin O. Leonard -- Predictive Toxicology: Genetics, Genomics, Epigenetics, and Next-Generation Sequencing in Toxicology / Tobias Heckel and Laura Suter-Dick -- Biomarkers as Tools for Predictive Safety Assessment: Novel Markers of Drug-Induced Kidney Injury / Angela Mally -- The Use of Renal Cell Culture for Nephrotoxicity Investigations / Anja Wilmes and Paul Jennings -- The Zebrafish Model in Toxicology / Natalie Mesens -- Predictive Method Development: Challenges for Cosmetics and Genotoxicity as a Case Study / Gladys Ouédraogo, Fabrice Nesslany, Sophie Simar, Smail Talahari, Doris Lagache, Eric Vercauteren, Lauren Nakab, Astrid Mayoux, Brigitte Faquet, and Nicole Flamand -- Using Pluripotent Stem Cells and Their Progeny as an in vitro Model to Assess (Developmental) Neurotoxicity / Lisa Hoelting, Marcel Leist, and Luc Stoppini -- Stem Cell-Based Methods for Identifying Developmental Toxicity Potential / Jessica A. Palmer, Robert E. Burrier, Laura A. Egnash, and Elizabeth L.R. Donley -- Immunogenicity of Protein Therapeutics: Risk Assessment and Risk Mitigation / Harald Kropshofer -- Regulatory Aspects / Beatriz Silva Lima
N2  - Tailored to the needs of drug developers, this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety asessment. With a keen emphasis on novel approaches, the topics have been tackled by selected expert scientists, who are familiar with the theoretical scientific background as well as with the practical application of current methods. Emerging technologies in toxicity assessment are introduced and evaluated in terms of their predictive power, with separate sections on computer predictions and simulation
UR  - http://onlinelibrary.wiley.com/
ER  -