Catalytic asymmetric reactions of conjugated nitroalkenes /
Irishi N.N. Namboothiri, Meeta Bhati, Madhu Ganesh, Basavaprabhu Hosamani, Thekke V. Baiju, Shimi Manchery, and Kalisankar Bera.
- First edition.
- 1 online resource (xviii, 301 pages) : illustrations
Catalytic asymmetric Michael addition of 1,3-dicarbonyls to nitroalkenes -- Catalytic asymmetric Michael addition of aldehydes to nitroalkenes -- Catalytic asymmetric Michael addition of ketones to nitroalkenes -- Catalytic asymmetric Michael addition of miscellaneous carbonyl compounds to nitroalkenes -- Catalytic asymmetric friedel-crafts reactions of nitroalkenes -- Catalytic asymmetric Michael addition of miscellaneous carbon centered nucleophiles to nitroalkenes -- Catalytic asymmetric Michael addition of heteroatom centered nucleophiles to nitroalkenes -- Catalytic asymmetric cycloadditions of nitroalkenes -- Catalytic asymmetric reduction of nitroalkenes -- Catalytic asymmetric synthesis of cycloalkanes via cascade reactions of nitroalkenes -- Catalytic asymmetric synthesis of aryl fused heterocycles via cascade reactions of nitroalkenes -- Catalytic asymmetric synthesis of five- and six-membered heterocycles via cascade reactions of nitroalkenes.
"Nitroalkenes have often been referred to as "synthetic chameleons" owing to their reactivity, synthetic utility and biological significance. In the last two decades, the reactivity of nitroalkenes as substrates in diverse catalytic asymmetric transformations has been of tremendous interest. This is due to the powerful electron withdrawing and co-ordinating ability of the nitro group and the amenability of the nitro group to undergo a wide variety of synthetic transformations. Although numerous original articles and reviews have appeared in the literature, a monograph providing comprehensive coverage of this topic was conspicuous by its absence. In the light of the above, this book features: A systematic, up-to-date, in-depth and well organized compilation, spread over twelve chapters, of various catalytic asymmetric reactions of nitroalkenes with diverse substrates reported till date Wide coverage of reactions such as Michael additions, Friedel-Crafts reactions, cycloadditions, asymmetric reductions, multi-component and cascade reactions as well as other miscellaneous reactions Various chiral organo-, metal- and even bio-catalysts involved in the stereoselective synthesis of multi-functional adducts via catalytic asymmetric reactions of nitroalkenes Schemes and figures detailing all the reagents, reaction conditions and product profile Mechanistic details, including transition state models, which will be useful for effective catalytic design This book will be an invaluable resource for those who are working in the area of asymmetric catalysis and synthetic methodologies"--