Pharmaceutical Biocatalysis : Drugs, Genetic Diseases, and Epigenetics / edited by Peter Grunwald.

Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Preface -- Chapter 1: Fermentative Production of Vitamin B6 -- 1.1: Introduction -- 1.2: De novo Synthesis of Vitamin B6 -- 1.3: Control of Vitamin B6 Homeostasis -- 1.4: Engineering Microorganisms for the Production of B6 Vitamers -- 1.5: Novel Routes for Vitamin B6 Biosynthesis and Production -- 1.6: Rational Design and Construction of a Vitamin B6-Producing Bacterium -- 1.7: Alternative Approaches for Enhancing Vitamin B6 Production -- 1.8: Conclusions

Chapter 4: Microbial Biotransformations in the Production and Degradation of Fluorinated Pharmaceuticals -- 4.1: Introduction -- 4.2: Fluorinated Natural Products -- 4.3: Production of Fluorinated Antibiotics in Microorganisms -- 4.4: Biological Production of [18F]-Labelled Compounds for PET Analysis -- 4.5: Microorganisms that Enable Fluorinated Drug Design -- 4.6: Production of Fluorinated Drug Metabolites in Microorganisms -- 4.7: Microbial Degradation of Fluorinated Drugs -- 4.8: Future Prospects and Challenges

Volume 7 of the Jenny Stanford Series on Biocatalysis deals with several different aspects of pharmaceuticals, which include not only various applications of drugs and their metabolism but also natural resources for active pharmaceutical ingredients as well as the removal of pharmaceutical pollution. In detail, novel approaches for developing microbial fermentation processes to produce vitamin B6 using microorganisms are described together with novel routes for vitamin B6 biosynthesis. The other topics discussed are new approaches for producing the successful anticancer drug Taxol from naturally occurring precursors, molecular farming through plant engineering as a cost-effective means to produce therapeutic and prophylactic proteins, and successful screening of potent microorganisms producing L-asparaginase for various chemotherapeutic applications. Furthermore, microbial biotransformations in the production and degradation of fluorinated pharmaceuticals are described. The other chapters inform the reader about the biotransformation of xenobiotics/drugs in living systems, the degradation of pharmaceuticals by white-rot fungi and their ligninolytic enzymes, and the removal of pharmaceutical pollution from municipal sewage using laccase.

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