Computational analysis of HIV drug resistance data
Beerenwinkel, N.
Computational analysis of HIV drug resistance data - Aachen Shaker Verlag 2004 - viii, 180p.
Examines computational ways for the analysis of integrated viral sequence data, phenotopic resistance data and clinical data from HIV-infected patients. A mixture model of trees to describe probabilistically the evolution of drug resistance is introduced and a useful learning algorithm presented. A scoring function for drug combinations that includes estimating the genetic barrier of the combination therapy relative to the viral strain is developed to support therapy optimisation.
3-8322-2639-7
Acquired Immunodeficiency Syndrome|HIV|Drug Resistance
WC 503 .B44 2004
Computational analysis of HIV drug resistance data - Aachen Shaker Verlag 2004 - viii, 180p.
Examines computational ways for the analysis of integrated viral sequence data, phenotopic resistance data and clinical data from HIV-infected patients. A mixture model of trees to describe probabilistically the evolution of drug resistance is introduced and a useful learning algorithm presented. A scoring function for drug combinations that includes estimating the genetic barrier of the combination therapy relative to the viral strain is developed to support therapy optimisation.
3-8322-2639-7
Acquired Immunodeficiency Syndrome|HIV|Drug Resistance
WC 503 .B44 2004